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KMID : 0382319890090010047
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Environmental Mutagens and Carcinogens
1989 Volume.9 No. 1 p.47 ~ p.55
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Modifying Effects of Capsaicin, Allyl Sulfide, Indole-3-Carbinol and Germanium on the Induction of Pepsinogen 1 Altered Pyloric Glands in Rats Initiated with N-Methyl-N`-Nitro-N-Nitrosoguanidine
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Jang Ja-June
Cho Kyung-Ja
Myong Na-Hye
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Abstract
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Quantitative analyses were made of pepsinogen 1 (Pg 1) decreased pyloric glands after treating male Wistar rats with N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) and NaCl and then with various test chemicals. Animals received MNNG in drinking water (100ng/ml) and 10% NaCl in diet for 8 weeks (group1), followed by basal diet containing 0.01% capsaicin, 0.5% allyl sulfide, 0.5% indole-3-carbinol and 0.05% germanium until 20 weeks (groups 2-5).
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